级研究生专业英语鄢业鸿.docx
- 文档编号:17276236
- 上传时间:2023-07-23
- 格式:DOCX
- 页数:12
- 大小:28.17KB
级研究生专业英语鄢业鸿.docx
《级研究生专业英语鄢业鸿.docx》由会员分享,可在线阅读,更多相关《级研究生专业英语鄢业鸿.docx(12页珍藏版)》请在冰点文库上搜索。
级研究生专业英语鄢业鸿
:
HPB(Oxford).2009;11(6):
499-504.
Links
Influenceofresectionmarginonsurvivalinhepaticresectionsforcolorectallivermetastases.
VandeweyerD,NeoEL,ChenJW,MaddernGJ,WilsonTG,PadburyRT.
BACKGROUND:
Traditionallya1-cmmarginhasbeenacceptedasthegoldstandardforresectionofcolorectallivermetastases.Evidenceisemergingthatalessermarginmayprovideequallyacceptableoutcomes,butacriticalmargin,belowwhichrecurrenceishigherandsurvivalpoorer,hasnotbeenuniversallyagreed.Inarecentpublication,wereportedperi-operativemorbidityandclearmarginasthetwoindependentprognosticfactors.Theaimofthecurrentstudywastofurtheranalysetheeffectofthewidthofthesurgicalmarginonpatientsurvivaltodeterminewhetheramarginof1mmisadequate.
METHODS:
Twohundredandsixty-oneconsecutiveprimaryliverresectionsforcolorectalmetastaseswereanalysedfrom1992to2007.Theresectionmarginswereassessedbymicroscopicexaminationofparaffinsections.Theinitialanalysiswasperformedonfivegroupsaccordingtotheresectionmargins:
involvedmargin,0-1mm,>1-<4mm,4-<10mmand>/=10mm.Subsequentanalysiswasbasedontwogroups:
margin<1mmand>1mm.
RESULTS:
Withamedianfollow-upof4.7years,theoverall5-yearpatientanddisease-freesurvivalwere38%and22%,respectively.Therewasnosignificantdifferenceinpatient-ordisease-freesurvivalbetweenthethreegroupswithresectionmargins>1mm.Whenacomparisonwasmadebetweenpatientswithresectionmargins=1mmandpatientswithresectionmargins>1mm,therewasasignificant5-yearpatientsurvivaldifferenceof25%versus43%(P<0.04).However,thedisease-freesurvivaldifferencedidnotreachstatisticalsignificance(P=0.14).
CONCLUSIONS:
Inthiscohortofpatients,wehavedemonstratedthataresectionmarginofgreaterthan1mmisassociatedwithsignificantlyimproved5-yearoverallsurvival,comparedwithinvolvedmarginsormarginslessthanorequalto1mm.Thepossiblebeneficialeffectofgreatermarginsbeyond1mmcouldnotbedemonstrated.
Hepatogastroenterology.2009May-Jun;56(91-92):
824-8.
Links
Effectofexcessiveacute-phaseresponseonliverregenerationafterpartialhepatectomyinrats.
KusashioK,ShimizuH,KimuraF,YoshidomeH,OhtsukaM,KatoA,YoshitomiH,FurukawaK,FukadaT,MiyazakiM.
DepartmentofGeneralSurgery,GraduateSchoolofMedicine,ChibaUniversity,Chiba,Japan.
BACKGROUND/AIMS:
Acute-phaseresponse(APR)isknowntohaveaprotectiveroleagainstinfectionandtissueinjuryincludingpartialhepatectomy(HTX).Inthisstudy,theeffectofexcessiveAPRonliverregenerationwasinvestigatedusingarathepatectomizedmodel.
METHODOLOGY:
ExperimentalAPRwasinducedbysubcutaneousinjectionofturpentineoil,immediately,24hand48hafter50%HTX.SerumIL-6andhepaticalpha2-macroglobulinmRNAwasevaluatedinratsreceivingturpentineorsalineascontrolafterHTX.DNAsynthesisandPCNAlabelingindexintheremnantliverwasalsoinvestigated.Furthermore,invitrototalhepaticproteinsynthesis(TPS)andsecretoryproteinsynthesis(SPS)intheremnantliverweremeasured
.RESULTS:
LiverregenerationwassignificantlyinhibitedafterHTXintheturpentinegroup,comparedtothecontrol.DNAsynthesisandPCNAlabelingindexwasalsosignificantlydecreasedondays1and2.AremarkableincreaseintheserumIL-6andhepaticalpha2-macroglobulinmRNAwasfoundintheturpentinegroup.Furthermore,SPSwassignificantlyupregulatedintheturpentinegroup,althoughTPSwasalmostsimilarbetweenthegroups.
CONCLUSIONS:
InductionofexcessiveAPRafterHTXinhibitsliverregeneration.Acutephaseproteinsynthesisisremarkablyupregulatedwithinthecapacityofhepaticproteinsynthesis,mostprobablybyareductioninreplicativeproteinsynthesis,suggestingthatAPRmaybemoreappropriatebiologicalresponseforensuringimmediatesurvival
SurgEndosc.2009Jun17.[Epubaheadofprint]
Links
Theimpactofcarbondioxidepneumoperitoneumonliverregenerationafterliverresectioninaratmodel.
SchmidtSC,SchumacherG,KlageN,ChopraS,NeuhausP,NeumannU.
ClinicforGeneral,Visceral,andTransplantationSurgery,CharitéCampusVirchowClinic,UniversityofMedicineBerlin,AugustenburgerPlatz1,13353,Berlin,Germany,sven.schmidt@charite.de.
BACKGROUND:
Inrecentyears,laparoscopichepaticresectionisperformedbyanincreasingnumberofsurgeons.Despitemanyadvantagesofthelaparoscopicprocedure,itisunclearwhetherthepneumoperitoneumaffectsthepostoperativeliverregenerationafterliverresection.Thecurrentstudyaimedtoinvestigatetheinfluenceofacarbondioxide(CO
(2))pneumoperitoneumonliverregenerationinaratmodel.
METHODS:
Inthisstudy,60maleWistarratsweresubjectedto70%partialhepaticresection.Ofthese60animals,30underwentpreoperativepneumoperitoneumat9mmHgfor60min.Afterhepaticresection,theratswerekilledat12,24,and48h,andondays4and7.Theoutcomeparameterswerehepatocellularinjury(plasmaaminotransferases),oxidativestress(plasmamalondialdehyde),interleukin-6(IL-6),andliverregeneration(mitoticindex,KI-67;regeneratinglivermass).
RESULTS:
Themitoticindexwassignificantlylowerinthepneumoperitoneumgroupthaninthegroupwithoutpneumoperitoneumatalltimepoints(p<0.05).Inthepneumoperitoneumgroup,KI-67wassignificantlyloweronday4(p<0.05).Theliverregenerationratewassignificantlylowerfortheanimalswithpneumoperitoneumondays2and4(p<0.05).Thepostoperativehepatocellularinjurywassignificantlygreaterafterpneumoperitoneumat12,24,and48h(p<0.05).PlasmamalondialdehydeandIL-6weresignificantlyhigherinthepneumoperitoneumgroupat24handonday4(p<0.05).
CONCLUSION:
Thisstudyshowedthatpneumoperitoneumbeforeextendedliverresectionimpairedpostoperativeliverregeneration.Oxidativestressreactionandhepatocellulardamagewasmarkedlyhigherafterpneumoperitoneum.Furtherinvestigations,especiallywithpatientsthathaveimpairedliverfunction,arenecessaryforclinicalconsequencestobedrawnfromtheseresults.
JSurgOncol.2011Nov1;104(6):
592-7.doi:
10.1002/jso.22022.Epub2011Jul8
Prognosticimpactofmicroscopicpositivemarginingastriccancerpatients.
NagataT,IchikawaD,KomatsuS,InoueK,ShiozakiA,FujiwaraH,OkamotoK,SakakuraC,OtsujiE.
Source
DivisionofDigestiveSurgery,DepartmentofSurgery,KyotoPrefecturalUniversityofMedicine,Kamigyo-ku,Kyoto,Japan.
Abstract
BACKGROUND:
Completeresectionwithnegativesurgicalmarginshasbeenalong-heldsurgicalphilosophybasedontheconceptthatevenminimalremainingcancercellswilldeveloprecurrences.
OBJECTIVES:
Thisstudyinvestigatedtheclinicalsignificanceofmicroscopicpositivemarginontheoutcomeofpatientswithgastriccancers.
METHODS:
Therelationshipsbetweenthemarginstatusandotherclinicopathologicfactorswereexaminedingastriccancerpatientsundergoinggastrectomy,andthentheprognosticimpactofthemarginstatuswasevaluatedbyunivariateandmultivariateanalysis.
RESULTS:
Themicroscopicpositivemarginwasidentifiedin23patients(2.8%)bystandardH&Estaining.Thepositivemarginshowedastrongcorrelationsignificantlywithtumorsize(P < 0.05).Microscopicpositivemarginwasfoundtobeasignificantprognosticfactoronunivariateanalysis(5-yearsurvivalrate51.9%vs.82.2%,P < 0.0001),aswellasmultivariateanalysis(riskratio3.24,95%CI:
1.24-6.50,P < 0.01).Detailedanalysisofmarginstatusdemonstratedthatpatientswithpositivemargininadeepsiteand/orinmultiplelayersshowedpoorsurvival.
CONCLUSIONS:
Microscopicpositivemarginwasfoundtobeanindependentprognosticfactoringastriccancerpatients.Thestatusofthesurgicalmarginmightprovideusefulinformationforselectingadditionaltreatmentsandperformingintensivefollow-up.J.Surg.Oncol.2011;104:
592-597.©2011WileyPeriodicals,Inc.
EurJSurgOncol.2011Sep24.[Epubaheadofprint
Comparisonofsurgicalperformanceandshort-termclinicaloutcomesbetweenlaparoscopicandroboticsurgeryindistalgastriccancer.
EomBW,YoonHM,RyuKW,LeeJH,ChoSJ,LeeJY,KimCG,ChoiIJ,LeeJS,KookMC,RheeJY,ParkSR,KimYW.
Source
GastricCancerBranch,NationalCancerCenter,111Jeongbalsanro,Ilsandong-Gu,Goyang-Si,Gyeonggi-Do410-769,SouthKorea.
Abstract
AIMS:
Theauthorsaimedtocomparethesurgicalperformanceandtheshort-termclinicaloutcomesofroboticassistedlaparoscopicdistalgastrectomy(RADG)withlaparoscopy-assisteddistalgastrectomy(LADG)indistalgastriccancerpatients.
METHOD:
FromApril2009toAugust2010,62patientsunderwentLADGand30patientsunderwentRADGforpreoperativestageIdistalgastriccancerbyonesurgeonattheNationalCancerCenter,Korea.Surgicalperformancewasmeasuredusinglymphnode(LN)dissectiontimeandnumberofretrievedLNs,whichwereviewedassurrogatesoftechnicaleaseandoncologicquality.
RESULTS:
Inclinicopathologiccharacteristics,meanage,depthofinvasionandstageweresignificantlydifferentbetweentheLADGandRADGgroup.MeandissectiontimeateachLNstationwasgreaterintheRADGgroup,butnosignificantintergroupdifferencewasfoundfornumbersofretrievedLNs.Furthermore,proximalresectionmarginsweresmaller,andhospitalcostswerehigherintheRADGgroup.IntermsoftheRADGlearningcurve,meanLNdissectiontimewassmallerinthelateRADGgroup(n = 15)thanintheearlyRADGgroup(n = 15)for4sb/4d,5,7-12astations,butnumbersofretrievedLNsperstationweresimilar.
CONCLUSION:
Withthe
- 配套讲稿:
如PPT文件的首页显示word图标,表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制:
部分文档作品中含有的国旗、国徽等图片,仅作为作品整体效果示例展示,禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词:
- 研究生 专业 英语 鄢业鸿