化学分析员面试常见问题.docx
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化学分析员面试常见问题.docx
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化学分析员面试常见问题
Ifotherstreatyouwell,youmustbeabletorepayyouinthefuture.Ifotherstreatyoubadly,youmuststrivetobeabletoraiseyoureyebrowsoneday.简单易用 轻享办公(WORD文档/A4打印/可编辑/页眉可删)
化学分析员面试常见问题
1、鉴别检查在药品质量控制中的意义及一般杂质检查的主要项目是什么?
Whatarethepurposesofdrugidentificationandtest?
Whataretheusualitemsofdrugtests?
.
2、比色比浊操作应遵循的原则是什么?
Whatarethestandardoperationproceduresfortheclaritytest?
3、试计算葡萄糖重金属检查中标准铅溶液的取用量。
Howmuchoftheleadstandardsolutionshouldbetakenforthelimittestforheavymetalsinthisexperiment?
4、古蔡氏试砷法中所加各试剂的作用与操作注意点是什么?
Whatprecautionsshouldbetakenforthelimittestforarsenic(AppendixVIIIJ,method1)?
Andwhatisthefunctionforeachofthetestsolutionsadded?
5、根据样品取用量、杂质限量及标准砷溶液的浓度,计算标准砷溶液的取用量。
Figureouttheamountofthearsenicstandardsolutionthatshouldbetakenforthelimittestforarsenic(AppendixVIIIJ,method1)(0.0001%)inthisexperimentwiththespecifiedquantityof2.0gofsample.
6、炽灼残渣测定的成败关键是什么?
什么是恒重?
Whatisthekeystepduringthedeterminationofresidueonignition?
Whatdoes‘igniteordrytoconstantweight’mean?
7、盐酸普鲁卡因的鉴别原理是什么?
WhataretheprinciplesoftheidentificationofProcaineHydrochloride.
8、盐酸普鲁卡因注射液中为什么要检查对氨基苯甲酸?
Whyisthelimitof4-aminobenzoicacidtestedforProcaineHydrochloride?
9、薄层色谱法检查药物中有关物质的方法通常有哪几种类型?
本实验属于哪种?
与其它方法有何异同点?
Howmanykindsofthelimittestsforrelatedcompoundsarethere?
Whatarethedifferencesbetweenthem?
Whichoneisusedforthelimittestof4-amino-benzoicacidinProcaineHydrochlorideInjection?
10、醋酸氢化可的松的鉴别原理是什么?
Whataretheprinciplesoftheidentificationofhydrocortisoneacetate?
11、甾体激素中“其它甾体”检查的意义和常用方法是什么?
Whatarethecommonlyusedmethodforandthesignificanceofthelimittestforothersteroidsforthesteroidaldrugs?
12、哪类甾体激素可与四氮唑蓝产生反应,是结构中的何种基团参与了反应,反应式是什么?
WhatkindofsteroidaldrugscanreactwiththealkalinetetrazoliumblueTS?
Whatisthechemicalreactionequation?
13、氯贝丁酯的鉴别原理是什么?
Whataretheprinciplesoftheidentificationofclofibrate?
14、氯贝丁酯中为什么要检查对氯酚?
其方法及原理是什么?
Whyisthelimitofp-Chlorophenoltestedforclofibrate?
Whatkindofmethodisemployedforthetestandwhatistheprinciple?
15、气相色谱法检查杂质有哪些方法,试比较各种方法的特点?
Howmanytypesofmethodsarethereforthetestofrelatedcompoundsbythegaschromatography?
Whatarethedifferencesbetweenthem?
16、抗生素类药物的鉴别和检查有何特点?
Whatarethecharacteristicsfortheidentificationandtestsofantibiotics?
17、钠盐的焰色反应应注意什么?
Whatprecautionsshouldbetakenduringtheflamereactionofsodiumsalts?
18、本品吸收度检查的意义是什么?
Whatisthepurposeofthelightabsorptiontestsforbenzylpenicillinsodium?
19、药物晶型测定的常用方法有哪些,各有什么特点?
Whatarethecommonlyusedmethodsforthetestofpolymorphism?
Andwhatarethecharacteristicsofeachofthem?
20、吸收系数测定方法与要求?
Whatarethestandardoperationproceduresfortheestablishmentofspecificabsorbance?
21、写出异烟肼与溴酸钾的滴定反应式和滴定度的计算过程。
Whatarethechemicalreactionequationsandtheequivalentrelationshipfortheassayofisoniazidbythemethodofpotassiumbromate(0.01667mol/L)VStitration.
22、当游离肼不合格时,对测定有何影响?
Ifthetestforthefreehydrazinedoesnotcomply,whatwillhappentotheresultsoftheassayofisoniazidbythepotassiumbromatetitration?
23、葡萄糖旋光度法测定含量时,为什么要加氨试液并放置后进行测定?
WhyshouldtheammoniaTSbeaddedtothesolutionwhichisthenallowedtostandfor10minutesintheassayofglucosebythemethodofopticalrotation?
24、推算出旋光度法测定葡萄糖含量时的计算系数2.0852;Figureoutthecoefficientof2.0852inthecalculationoftheglucosecontentintheassayofglucosebythemethodofopticalrotation.
25、写出剩余碘量法测定葡萄糖化学反应过程。
Figureoutthechemicalreactionequationsandtheequivalentrelationshipfortheassayofglucosebythemethodofiodinetitration.
26、哪些巴比妥药物能用银量法进行含量测定?
为什么?
Whatkindofbarbitalscanbeassayedbythepotentiometrictitrationwithsilvernitrate?
27、水溶液银量法电位滴定中采用的电极系统是什么?
Whattypeofelectrodepairsshouldbeusedforthepotentiometrictitrationwithsilvernitrate?
28、写出高氯酸滴定硫酸奎尼丁的滴定反应式并计算滴定度?
FigureoutthechemicalreactionequationofQuinidineSulfatewithper-chloricacidandtheequivalentrelationship.
29、非水滴定法中常见酸根的影响如何消除?
Howtocircumventtheinterferencesofotheracidduringthenon-aqueoustitrationofbasicdrugswithperchloricacid?
30、非水滴定的注意事项有哪些?
常用终点指示方法是什么?
Whatprecautionsshouldbetakenduringthenon-aqueoustitration?
Whatarethecommonlyusedmethodsfortheend-pointindicatingduringthetitration?
31、写出亚硝酸钠滴定盐酸普鲁卡因的滴定反应式并计算滴定度?
FigureoutthechemicalreactionequationofProcaineHydrochloridewithsodiumnitriteandtheequivalentrelationship.
32、亚硝酸钠滴定的适用范围是什么?
注意事项有哪些?
常用终点指示方法有哪些?
Whattypeofcompoundsmaybeassayedwiththedead-stoptitrationbysodiumnitrite?
Whatprecautionsshouldbetakeninthedead-stoptitration?
Whatotherend-pointindicatingmethodsarethere?
33、氧瓶燃烧操作的注意事项有哪些?
Whatprecautionsshouldbetakentoconducttheoxygenflaskcombustionmethod?
34、如何选择氧瓶燃烧法的吸收溶液?
Howtoselecttheabsorbingliquidfortheoxygenflaskcombustionmethod?
35、氧瓶燃烧法在药物分析中的主要应用有哪些?
Whatarethemajorapplicationsoftheoxygenflaskcombustionmethodintheanalysisofdrugs?
36、为什么供肌内注射用肌甘注射液含量测定时必须先进行纸色谱分离?
Whyisthepa-pe-rchromatographicseparationusedfortheassayofintramascularinjectionofinosine?
37、本测定法平行试验相对误差的限度应该小于多少?
Whatistherequirementoftheprecisionoftheassayofinosineforintramascularinjection?
38、各国药典中维生素A的含量测定为什么都采用分光光度方法?
WhyarethespectrophotometricassaymethodusedfortheassayofVitaminAinallthepharmacopoeias?
39、试推导出各种不同情况下维生素A含量测定的计算式。
FigureoutalltheequationsforthecalculationofthecontentofVitaminA
40、气相色谱测定维生素E含量时为什么使用内标法?
WhyistheinternalreferencestandardmethodemployedfortheassayofVitaminEbyGC?
41、试述气相色谱法的特点及分析适用范围。
GiveanexplanationofthefeaturesandapplicationsofGCmethod?
42、维生素E含量测定的其它方法有哪些?
各有什么特点?
WhatothermethodsaretherefortheassayofVitaminE?
43、阿司匹林原料药物与及阿司匹林肠溶片在质量检验方面有哪些不同之处?
为何不同?
Whatisthedifferencebetweentheassayofaspirinanditsenteric-coatedtablets?
44、阿司匹林肠溶片释放度检查中为什么要更换溶剂?
Giveanexplanationofthepurposeofthesolventchangingduringthedrugreleasetestofaspirinenteric-coatedtablets.
45、氢溴酸东莨菪碱的鉴别原理是什么?
Whatarethechemicalreactioncharacteristicsoftropanealkaloids?
46、氢溴酸东莨菪碱片含量测定的方法与原理是什么?
Whatkindofmethodisemployedfortheassayofscopolaminehydrobromidetablets?
47、氢溴酸东莨菪碱片含量均匀度检查的意义是什么?
Whyisthecontentuniformitytestedforthescopolaminehydrobromidetablets?
48、本品中甲苯咪唑的含量为什么可以用分光光度法测定?
Whycanthecontentofmebendazoleofthiscompoundtabletbeassayedbythespectrophotometricmethod?
49、本品中盐酸左旋咪唑含量测定时,为什么甲苯咪唑没有干扰?
Whydoesmebendazolenotinterferewiththetitrationoflevamisolehydrochlorideinchloroform?
50、分别说明本品中磺胺甲噁唑和甲氧苄啶双波长法含量测定时波长选择的依据;Giveanexplanationofthebasisofthewavelengthselectionforthedeterminationofsulfamethoxazoleandtrimethoprim,respectively.
51、为何甲氧苄啶含量测定时供试液的稀释倍数与磺胺甲噁唑测定时的要不同?
Whyisthemoredilutedsolutionusedfortheassayoftrimethoprimthanthatforsulfamethoxazole?
52、本品HPLC法检验色谱系统适用性试验有什么意义?
WhatisthesystemsuitabilitytestoftheHPLCmethod?
GiveanexplanationoftheimportanceofthesystemsuitabilitytestoftheHPLCmethodduringtheassayandthetestofrelatedsubstances.
53、药品含量以干燥品计算或无水物计算有何不同?
Whatisthedifferencebetweenthecontentsofdrugswhenitiscalculatedontheanhydrousbasisandonthedriedbasis?
54、写出盐酸克仑特中2,4-二硝基苯肼鉴定的化学反应式。
Whatarethecompletechemicalprocessesoftheidentificationofclenbuterolhydrochlorideby2,4-dinitrophenylhydrazine.
55、盐酸克仑特中总氯量测定的滴定方法是什么?
滴定过程中加硝基苯并强力振摇的目的`是什么?
Whatkindoftitrationmethodisemployedforthetotalchloridetestforclenbuterolhydrochloride?
Whatisthepurposeoftheadditionof3mlofnitrobenzeneandshakingvigorously?
56、盐酸克仑特含量测定采用的永停滴定法的原理是什么?
有哪些注意事项?
Whatistheprincipleofpotentio-metrictitrationfortheassayofclenbuterolhydrochloride?
Whatprecautionsshouldbetakenduringthetitration?
57、试述抗生素药物有关物质检查的意义?
Whatistheimportanceofthetestofrelatedsubstancesforantibiotics.
58、头孢克洛水分测定的意义?
Whatisthepurposeforthetestandcontrolofwatercontentforantibiotics?
59、抗生素药物含量或效价测定的方法有哪些?
各有什么特点?
Whatothermethodsaretherefortheassayofantibiotics?
Giveanexplanationofthecharacteristicsofeachmethod.
60、槐花的主要化学成分有哪些?
WhatkindofchemicalsarethereintheFlosSophorae?
61、药材浸出测定方法中,冷浸法与热浸法各有什么特点?
水浸出物与醇浸出物有什么区别?
Whatisthedifferencebetweenthehotandcoldextractionmethodsasdescribedunderthedeterminationofextractives?
Whatisthedifferencebetweentheethanol-solubleandwater-solubleextractives?
62、槐花与镁粉-盐酸反应鉴别的化合物的类别是什么?
反应原理是什么?
Whatkindofcompoundsareidentifiedbythecolorreactionwithasmallquantityofmagnesiumpowderand2~3dropsofhydrochloricacid?
Whatarethereactionprocesses?
63、槐花比色法含量测定的原理是什么?
先加乙醚加热回流提取的目的是什么?
Whatistheprincipleofthephotometricassayofthisdrug?
WhatisthepurposeoftheSoxhiet'sextractionwithether?
64、石菖蒲的主要化学成分有哪些?
WhatkindsofcomponentsarethereinthevolatileoilobtainedundertheAssay?
65、石菖蒲挥发油用甲法进行测定;若用乙法测定须加入二甲苯1.0ml,其目的是什么?
Thefirstmethodforthedeterminationofvolatileoilisemployedfortheassay.Whatisthepurposefortheadditionof1.0mlofxyleneifthesecondmethodwasemployed?
66、供挥发油测定用的供试品,须粉碎使能通过二号至三号筛,为什么?
Whatshouldbedonetothedrugbeforethedeterminationofvolatileoil?
67、中成药含量测定及鉴别试验中检测对象的选择原则有哪些?
本品为什么选择丹皮酚和熊果酸进行含量测定?
Whyarepaeonolandursolicacidselectedfortheassayofthisdrug?
WhatistheprinciplefortheassayandidentificationoftraditionalChinesemateriamedica?
68、熊果酸含量薄层扫描法测定时,用10%硫酸乙醇喷雾显色后,薄层板上为什么要覆盖同样大小的玻璃板?
Whyshouldtheplatebecoveredwithaglassplateofthesamesizeandfixedupwithadhesiveplasterintheassayofursolica
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