免疫学试题A卷及答案.docx
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免疫学试题A卷及答案.docx
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免疫学试题A卷及答案
Thefinalexaminationofmedicalimmunology
forsevenyearstudentsofGrade2003(2005/12/6)
PaperA
题号
一
二
三
四
五
总分
统分人
得分
得分
评卷人
I.Explainthefollowingitems(2pointsforeach,18points)
1.Lymphocyterecirculation
扣分
2.CDR
扣分
3.cytokine
扣分
4.MHCrestriction
扣分
5.PRR
扣分
6.Immunetolerance
扣分
7.ITAM
扣分
8.APC
扣分
9.TI-Ag
扣分
II.Chooseallcorrectanswers(1pointforeach,15points)
得分
评卷人
No.
1
2
3
4
5
6
7
8
Answer
No.
9
10
11
12
13
Answer
1.Whichofthefollowingstatement(s)aboutthespleenis(are)true:
A.Itfiltersantigensoutoftheblood.
B.Lymphaticvesselsdrainingthetissuespacesenterthespleen
C.Itcontainsgerminalcenters
D.Itfunctionstoremoveoldanddefectiveredbloodcells
2.WhichkindsofIgexpressedmainlyonthesurfaceofmatureBcells?
A.mIgGB.mIgAC.mIgDD.mIgM
3.WhichcanfunctionasC3convertaseinactivationofcomplementsystem?
A.C4b2bB.C4b2b3bC.C3bBbD.C3bnBb
4.Aboutthecharacteristicsofcytokines,whichofthefollowing(s)is(are)correct?
A.Onecytokinecanactondifferentcellsandplaymultiplebiologicaleffects
B.Thecytokineproducedbyonecellonlyactsonneighborcells
C.Combinedwithcorrespondingreceptortoplayrole
D.Onecytokinecaninhibitorenhanceeffectsofothercytokine
5.WhichofthefollowingmoleculescanstimulateTcellsactivation?
A.LPSB.PWMC.ConAD.PHA
6.WhatarethefunctionsofBcells?
A.produceAb
B.secretecytokines
C.killtargetcellsdirectly
D.presentAg
7.WhichofthecytokinesaresecretedbyTh1cells?
A.IL-4B.IL-2C.IL-10D.IFN-γ
8.WhichofthediseasesbelongtotypeⅢhypersensitivity?
A.Transfusionreaction
B.Arthusreaction
C.Contactdermatitis
D.Rheumatoidarthritis
9.Whichofthefollowingis(are)correctaboutthecharacteristicsofmemorycells?
A.CancomefromeitherBcellorTcell
B.Canrespondtoantigenatlowconsentrateeffectivelly
C.OnlyexistinHI
D.Reacttoasecondinvasionofanantigenmorerapidlyandstronger
10.Whatabilitiesdoαβ+Tcellsgainaftermaturation?
A.self-reactive
B.self-tolerance
C.expressfunctionalTCR
D.selfMHCrestriction
11.Whichofthefollowingsarecorrectstatementsaboutdendriticcells?
A.CanstimulatenaïveTcellproliferation
B.ExpresshighlevelofMHCclassIImolecules
C.ExpresshighlevelofMHCclassImolecules
D.Maturedendriticcellswithstrongfunctionofantigen-capture
12.AboutAICD,whichstatementsarecorrect?
A.CanbemediatedbyFasL-Fasinteraction
B.IsakindofcelldeathofactivatedTcell
C.Playimportantrolesinimmunologicalregulation
D.IL-4canpromoteAICD
13.Theprocessesofantigen-activatedBcellsdifferentiationingerminalcenterinclude:
A.IgClassswitching
B.SomatichypermutationandIgaffinitymaturation
C.DifferentiateintoBm
D.Apoptosis
14.Whichofthefollowingfactorsaffecttheantigenimmunogenecity?
A.moleculeweightB.foreigness
C.conformationD.chemicalcomposition
15.Aboutsomatichypermutation,whichstatementsarecorrect?
A.OccursduringBcellsmaturation
B.Resultinaffinitymaturationofantibodies
C.MainlyoccursinCDRregion
D.CanoccurduringTcellsmaturation
Ⅲ.Answerthefollowingquestionsbriefly(5pointforeach,30points)
得分
评卷人
1.HowcanThelpercellsplayimportantrolesinanantibodymediatedresponse.
扣分
2.WhatcellsexpresstheHLAIImolecules?
WhatarethefunctionsofHLAIImoleculesonthesecells?
扣分
3.IfwewanttolabeltheantibodywithenzymeforELISAexperiment,whatpartofantibodydoesenzymeshouldbindto?
Why?
扣分
4.HowdoeffectorspecificCTLskilltumorcells?
Whatarethecharacteristicsforthisprocess?
扣分
5.HowareendogenousantigensrecognizedbyCD8+Tcells?
扣分
6.WhatisNeonatehemolysis?
Pleasedescribeitsmechanism.
扣分
IV.Answerfollowingquestion(12points)
得分
评卷人
1.Howtheinnateandadaptiveimmunityactincooperativeandinter-dependentwaystoprotectthehost.?
扣分
Thefinalexaminationofmedicalimmunology
forsevenyearstudentsofGrade2003(2005/12/6)
PaperA
I.Explainthefollowingitems(2pointsforeach,18points)
1.Lymphocyterecirculation:
istheprocessbywhichlymphocytescontinuouslymovebetweensitesthroughoutthebody
(1)throughbloodandlymphaticvessels,anditiscriticalfortheinitiationandeffectorphasesofimmuneresponses
(1).
2.CDR:
Complementarity-determiningregion(0.5)
thethreeHVRofLchainandHchainarebroughttogethertoformantigen-bindingsurface,soHVRisalsocalledCDR
(1)
3.cytokine:
Agroupof(0.5)lowmoleculeweightproteins(0.5)whicharesecretedbyactivatedimmunocytesorsomematrixcells(0.5)andtakeeffectsbybindingcorrespondingreceptoroncells(0.5).
4.MHCrestriction:
IninteractionofTcellandantigen-presentingcell(APC)ortargetcell(0.5),Tcellnotonlyrecognizesspecificantigenpeptide,butalsorecognizespolymophicresidueofMHCmolecules(0.5).
5.Patternrecognitionreceptor(PRR):
Thereceptoronmacrophage(0.5)whichcanrecognizeandbindspecificmolecularstructureonsomepathogens,injuredorapoptoticcells(0.5).
6.Immunetolerance
aspecificnonreactivity1.0
towardsagivenantigen0.5
inothercircumstanceisabletoinducecell-mediatedorhumoralimmunity0.5
7.ITAM
immunoreceptortyrosine-basedactivationmotif0.5
transductactivationsignal1.0
composedoftwotyrosineresiduesseparatedbyaround18aminoacid-----whenantigenbinds,thetyrosinebecomephosphorylatedbythereceptorassociatedtyrosinekinasestotransductactivatorysignal0.5
8.APC
cellsthatcancapture(0.5),processantigen(0.5),andpresenttheantigenicpeptide/MHCclassIorIImolecules(0.5)toTcells(0.5)arecalledantigen-presentingcells.TheyarealsocalledAcell(Accessorycell).
9.TI-Ag(thymusindependentAg):
AgwhichcanstimulateBcellstoproduceAb(0.5)withoutthehelpofTcellandMФ(0.5).
II.Chooseallcorrectanswers(1pointforeach,15points)
No.
1
2
3
4
5
6
7
8
Answer
ACD
CD
AC
ACD
BCD
ABD
BD
BD
No.
9
10
11
12
13
14
15
Answer
ABD
BCD
ABC
ABC
ABCD
ABCD
ABC
Ⅲ.Answerthefollowingquestionsbriefly(5pointforeach,30points)
得分
评卷人
1.HowcanThelpercellsplayimportantrolesinanantibodymediatedresponse.
(1)ExpressCD40L(0.5),combinewithCD40expressingonBcell(0.5),provideco-stimulationsignalduringtheactivationofBcell
(1).
(2)SecreteIL-4,5,6(0.5)etc.topromoteproliferationanddifferentiationofBcell
(1)
(3)SecretecytokinestopromoteIgisotypeswitching(1.5).
2.WhatcellsexpresstheHLAIImolecules?
WhatarethefunctionsofHLAIImoleculesonthesecells?
cellsexpresstheHLAIImolecules
(2)
professionalAPC(macrophage,dentriticcellandBcell),
activatedTcell,
thymusepithelialcelletal.
thefunctionsofHLAIImolecules(1pointeach)
ØParticipateincontrollingThcell-APCrecognitioninimmunoreaction
ØParticipateinprocessingandpresentingofantigen
ØParticipateininducingthedifferentiationanddevelopmentofTcellinthymus
3.IfwewanttolabeltheantibodywithenzymeforELISAexperiment,whatpartofantibodydoesenzymeshouldbindto?
Why?
Fcfragment
(2),because:
FabbindstoAgspecifically
(1)
FchasnoeffectonAgbinding,soFccanbelabeledtodetectAg-AbcomplexwithouteffectiononitsAgbindingactivity
(2)
4.HowdoeffectorspecificCTLskilltumorcells?
Whatarethecharacteristicsforthisprocess?
•SpecificrecognitionandbindingoftargetcellbyCTL
•Lethalhittotargetcell
•Perforin1
•Granzyme1
•Fas/FasLpathway—apoptosis0.5
•Specifickilling1
•classⅠMHCmoleculerestriction1
•Continuouskillingoftargetcellsinshorttime,andnoinjuryofCTL0.5
5.HowareendogenousantigensrecognizedbyCD8+Tcells?
◆ByclassIMHCpathway1
◆ProcessingofendogenousAg:
proteosome-LMP2,LMP7,antigenpeptides(8-13aa)1
◆TransportingofantigenpeptideintoER:
TAP(transporterassociatedwithantigenprocessing)1
◆PeptideloadingofMHCImolecules:
ER,antigenpeptide—classⅠMHCcomplexes1
◆PresentingtoCD8+Tcells:
TCR-peptide,CD8-α31
6.WhatisNeonatehemolysis?
Pleasedescribeitsmechanism.
Definition:
MaternalIgGspecificforthefetalbloodgroupscrossestheplacentaanddestroysthefetalredbloodcells1
Mechanism:
MainlyinducedbyRhantigen.ItisTypeIIhypersensitivity0.5
RhantigensonthesurfaceoffetalredbloodcellsinduceIgGantibodyproductionwithinmotherbody---thefirstpregnancy.1
IgGcrossestheplacentaandbindwithRhantigentoformAg-Abcomplex---thesecondpregnancy.1
Celllysis:
Ag-Abcomplexactivatescomplementbyclassicpathway.
MAC0.5
ADCC0.5
OposinizationbyCandAbpromotesmacrophagesfunction.0.5
IV.Answerfollowingquestion(12points)
得分
评卷人
1.Howdotheinnateandadaptiveimmunityactincooperativeandinter-dependentwaystoprotectthehost?
Innateimmunity→adaptiveimmunity(8points)
(1)macrophageandDCparticipateinantigenicpresentationandinitiateadaptiveimmunity3points
(2)macrophage,NK,Complementetc.participateineffectorphageofadaptiveimmunity3points
(3)macrophageandNKsecretecytokinesregulatetypesofadaptiveimunity2points
Adaptiveimmunity→Innateimmunity(4points)
(1)Ab-Agcomplexsitumulateactivationofcomplementbyclassicalpathway1
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