IARC致癌物.docx
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IARC致癌物.docx
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IARC致癌物
IARC对致癌物的最新评价结果
OverallEvaluationsofCarcinogenicitytoHumans
Group1:
Carcinogenictohumans(100)
Agentsandgroupsofagents
4-Aminobiphenyl[92-67-1](Vol.1,Suppl.7;1987)
Arsenic[7440-38-2]andarseniccompounds(Vol.23,Suppl.7;1987)(NB:
Thisevaluationappliestothegroupofcompoundsasawholeandnotnecessarilytoallindividualcompoundswithinthegroup)
Asbestos[1332-21-4](Vol.14,Suppl.7;1987)
Azathioprine[446-86-6](Vol.26,Suppl.7;1987)
Benzene[71-43-2](Vol.29,Suppl.7;1987)
Benzidine[92-87-5](Vol.29,Suppl.7;1987)
Benzo[a]pyrene[50-32-8](Vol.32,Suppl.7,Vol.92;inpreparation)
(NB:
Overallevaluationupgradedfrom2Bto1basedonmechanisticandotherrelevantdata)
Beryllium[7440-41-7]andberylliumcompounds(Vol.58;1993)
N,N-Bis(2-chloroethyl)-2-naphthylamine(Chlornaphazine)[494-03-1](Vol.4,Suppl.7;1987)
Bis(chloromethyl)ether[542-88-1]andchloromethylmethylether[107-30-2](technical-grade)
(Vol.4,Suppl.7;1987)
1,4-Butanedioldimethanesulfonate(Busulphan;Myleran)[55-98-1](Vol.4,Suppl.7;1987)
Cadmium[7440-43-9]andcadmiumcompounds(Vol.58;1993)
Chlorambucil[305-03-3](Vol.26,Suppl.7;1987)
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea(Methyl-CCNU;Semustine)[13909-09-6](Suppl.7;1987)
Chromium[VI](Vol.49;1990)
Ciclosporin[79217-60-0](Vol.50;1990)
Cyclophosphamide[50-18-0][6055-19-2](Vol.26,Suppl.7;1987)
Diethylstilboestrol[56-53-1](Vol.21,Suppl.7;1987)
Epstein-Barrvirus(Vol.70;1997)
Erionite[66733-21-9](Vol.42,Suppl.7;1987)
Estrogen-progestogenmenopausaltherapy(combined)(Vol.72,Vol.91;inpreparation)
Estrogen-progestogenoralcontraceptives(combined)(Vol.72,Vol.91;inpreparation)
(NB:
Thereisalsoconvincingevidenceinhumansthattheseagentsconferaprotectiveeffectagainstcancerintheendometriumandovary)
Estrogens,nonsteroidal(Suppl.7;1987)(NB:
Thisevaluationappliestothegroupofcompoundsasawholeandnotnecessarilytoallindividualcompoundswithinthegroup)
Estrogens,steroidal(Suppl.7;1987)(NB:
Thisevaluationappliestothegroupofcompoundsasawholeandnotnecessarilytoallindividualcompoundswithinthegroup)
Estrogentherapy,postmenopausal(Vol.72;1999)
Ethyleneoxide[75-21-8](Vol.60;1994)(NB:
Overallevaluationupgradedfrom2Ato1withsupportingevidencefromotherrelevantdata)
Etoposide[33419-42-0]incombinationwithcisplatinandbleomycin(Vol.76;2000)
Formaldehyde[50-00-0](Vol.88;2006)
Galliumarsenide[1303-00-0](Vol.86;2006)
[GammaRadiation:
seeX-andGamma(g)-Radiation]
Helicobacterpylori(infectionwith)(Vol.61;1994)
HepatitisBvirus(chronicinfectionwith)(Vol.59;1994)
HepatitisCvirus(chronicinfectionwith)(Vol.59;1994)
Humanimmunodeficiencyvirustype1(infectionwith)(Vol.67;1996)
Humanpapillomavirustypes16,18,31,33,35,39,45,51,52,56,58,59and66(Vol.64,Vol.90;inpreparation)(NB:
TheHPVtypesthathavebeenclassifiedascarcinogenictohumanscandifferbyanorderofmagnitudeinriskforcervicalcancer)
HumanT-celllymphotropicvirustypeI(Vol.67;1996)
Melphalan[148-82-3](Vol.9,Suppl.7;1987)
8-Methoxypsoralen(Methoxsalen)[298-81-7]plusultravioletAradiation(Vol.24,Suppl.7;1987)
MOPPandothercombinedchemotherapyincludingalkylatingagents(Suppl.7;1987)
Mustardgas(Sulfurmustard)[505-60-2](Vol.9,Suppl.7;1987)
2-Naphthylamine[91-59-8](Vol.4,Suppl.7;1987)
Neutrons(Vol.75;2000)(NB:
Overallevaluationupgradedfrom2Bto1withsupportingevidencefromotherrelevantdata)
Nickelcompounds(Vol.49;1990)
N'-Nitrosonornicotine(NNN)[16543-55-8]and4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone(NNK)[64091-91-4](Vol.37,Suppl.7,Vol.89;inpreparation)(NB:
Overallevaluationupgradedfrom2Bto1basedonmechanisticandotherrelevantdata)
[Oestrogen:
seeEstrogen]
Opisthorchisviverrini(infectionwith)(Vol.61;1994)
[Oralcontraceptives,combinedestrogen-progestogen:
seeEstrogen-progestogenoralcontraceptives(combined)]
Oralcontraceptives,sequential(Suppl.7;1987)
Phosphorus-32,asphosphate(Vol.78;2001)
Plutonium-239anditsdecayproducts(maycontainplutonium-240andotherisotopes),asaerosols(Vol.78;2001)
Radioiodines,short-livedisotopes,includingiodine-131,fromatomicreactoraccidentsandnuclearweaponsdetonation(exposureduringchildhood)(Vol.78;2001)
Radionuclides,a-particle-emitting,internallydeposited(Vol.78;2001)
(NB:
SpecificradionuclidesforwhichthereissufficientevidenceforcarcinogenicitytohumansarealsolistedindividuallyasGroup1agents)
Radionuclides,b-particle-emitting,internallydeposited(Vol.78;2001)
(NB:
SpecificradionuclidesforwhichthereissufficientevidenceforcarcinogenicitytohumansarealsolistedindividuallyasGroup1agents)
Radium-224anditsdecayproducts(Vol.78;2001)
Radium-226anditsdecayproducts(Vol.78;2001)
Radium-228anditsdecayproducts(Vol.78;2001)
Radon-222[10043-92-2]anditsdecayproducts(Vol.43,Vol.78;2001)
Schistosomahaematobium(infectionwith)(Vol.61;1994)
Silica[14808-60-7],crystalline(inhaledintheformofquartzorcristobalitefromoccupationalsources)(Vol.68;1997)
Solarradiation(Vol.55;1992)
Talccontainingasbestiformfibres(Vol.42,Suppl.7;1987)
Tamoxifen[10540-29-1](Vol.66;1996)(NB:
Thereisalsoconclusiveevidencethattamoxifenreducestheriskofcontralateralbreastcancer)
2,3,7,8-Tetrachlorodibenzo-para-dioxin[1746-01-6](Vol.69;1997)(NB:
Overallevaluationupgradedfrom2Ato1withsupportingevidencefromotherrelevantdata)
Thiotepa[52-24-4](Vol.50;1990)
Thorium-232anditsdecayproducts,administeredintravenouslyasacolloidaldispersionofthorium-232dioxide(Vol.78;2001)
Treosulfan[299-75-2](Vol.26,Suppl.7;1987)
Vinylchloride[75-01-4](Vol.19,Suppl.7;1987)
X-andGamma(g)-Radiation(Vol.75;2000)
Mixtures
Aflatoxins(naturallyoccurringmixturesof)[1402-68-2](Vol.56,Vol.82;2002)
Alcoholicbeverages(Vol.44;1988)
Arecanut(Vol.85;2004)(NB:
Overallevaluationbasedonhumandata,animaldata,andmechanisticandotherrelevantdata)
Betelquidwithtobacco(Vol.85;2004)
Betelquidwithouttobacco(Vol.85;2004)
Coal-tarpitches[65996-93-2](Vol.35,Suppl.7;1987)
Coal-tars[8007-45-2](Vol.35,Suppl.7;1987)
HerbalremediescontainingplantspeciesofthegenusAristolochia(Vol.82;2002)
Householdcombustionofcoal,indooremissionsfrom(Vol.95;inpreparation)
Mineraloils,untreatedandmildlytreated(Vol.33,Suppl.7;1987)
Phenacetin,analgesicmixturescontaining(Suppl.7;1987)
Saltedfish(Chinese-style)(Vol.56;1993)
Shale-oils[68308-34-9](Vol.35,Suppl.7;1987)
Soots(Vol.35,Suppl.7;1987)
Tobacco,smokeless(Vol.37,Suppl.7,Vol.89;inpreparation)
Wooddust(Vol.62;1995)
Exposurecircumstances
Aluminiumproduction(Vol.34,Suppl.7;1987)
Arsenicindrinking-water(Vol.84;2004)
Auramine,manufactureof(Suppl.7;1987)
Bootandshoemanufactureandrepair(Vol.25,Suppl.7;1987)
Chimneysweeping(Vol.92;inpreparation)
Coalgasification(Vol.34,Suppl.7,Vol.92;inpreparation)
Coal-tardistillation(Vol.92;inpreparation)
Cokeproduction(Vol.34,Suppl.7,Vol.92;inpreparation)
Furnitureandcabinetmaking(Vol.25,Suppl.7;1987)
Haematitemining(underground)withexposuretoradon(Vol.1,Suppl.7;1987)
Involuntarysmoking(exposuretosecondhandor'environmental'tobaccosmoke)(Vol.83;2004)
Ironandsteelfounding(Vol.34,Suppl.7;1987)
Isopropylalcoholmanufacture(strong-acidprocess)(Suppl.7;1987)
Magenta,manufactureof(Vol.57;1993)
Painter(occupationalexposureasa)(Vol.47;1989)
Pavingandroofingwithcoal-tarpitch(Vol.92;inpreparation)
Rubberindustry(Vol.28,Suppl.7;1987)
Strong-inorganic-acidmistscontainingsulfuricacid(occupationalexposureto)(Vol.54;1992)
Tobaccosmokingandtobaccosmoke(Vol.83;2004)
Lastupdated:
13December2006
Group2A:
Probablycarcinogenictohumans(68)
Agentsandgroupsofagents
Acrylamide[79-06-1](Vol.60;1994)(NB:
Overallevaluationupgradedfrom2Bto2Awithsupportingevidencefromotherrelevantdata)
Adriamycin[23214-92-8](Vol.10,Suppl.7;1987)(NB:
Overallevaluationupgradedfrom2Bto2Awithsupportingevidencefromotherrelevantdata)
Androgenic(anabolic)steroids(Suppl.7;1987)
Aristolochicacids(naturallyoccurringmixturesof)(Vol.82;2002)
Azacitidine[320-67-2](Vol.50;1990)(NB:
Overallevaluationupgradedfrom2Bto2Awithsupportingevidencefromotherrelevantdata)
Benzidine-baseddyes(Suppl.7;1987)(NB:
Overallevaluationupgradedfrom2Bto2Awithsupportingevidencefromotherrelevantdata)
Bischloroethylnitrosourea(BCNU)[154-93-8](Vol.26,Suppl.7;1987)
1,3-Butadiene[106-99-0](Vol.71;1999)
Captafol[2425-06-1](Vol.53;1991)(NB:
Overallevaluationupgradedfrom2Bto2Awithsupportingevidencefromotherrelevantdata)
Chloramphenicol[56-75-7](Vol.50;1990)(NB:
Overallevaluationupgradedfrom2Bto2Awithsupportingevidencefromotherrelevantdata)
α-Chlorinatedtoluenes(benzalchloride[98-87-3],benzotrichloride[98-07-7],benzylchloride[100-44-7])andbenzoylchloride[98-88-4](combinedexposures)(Vol.29,Suppl.7,Vol.71;1999)
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea(CCNU)[13010-47-4](Vol.26,Suppl.7;1987)
(NB:
Overallevaluationupgradedfrom2Bto2Awithsupportingevidencefromotherrelevantdata)
4-Chloro-ortho-toluidine[95-69-2](Vol.77;2000)
Chlorozotocin[54749-90-5](Vol.50;1990)(NB:
Overallevaluationupgradedfrom2Bto2Awithsupportingevidencefromo
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