免疫习题 免疫细胞及其相关分子Immune exercises immune cells and related molecules.docx
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免疫习题 免疫细胞及其相关分子Immune exercises immune cells and related molecules.docx
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免疫习题免疫细胞及其相关分子Immuneexercisesimmunecellsandrelatedmolecules
免疫习题免疫细胞及其相关分子(Immuneexercises,immunecellsandrelatedmolecules)
Immuneexercises,immunecellsandtheirassociatedmolecules,.Txt,marry,arelikewearingacottonpaddedcoatforfree.It'snoteasytomove,butit'sverywarm.Fallinginloveislikepeelingonions.There'salwaysalayeroftearsgoingon.First,themultiple-choicequestion:
1.humanBlymphocytesurfacehas
A.sheeperythrocytereceptorB.FceR,C.CR2,D.HIVreceptor,classE.MHC,classIIreceptor
Theearliestsignof2.Bcelldifferentiationis
A.IggeneDNArearrangement,B.cytoplasm,IgM,C.membrane,IgDappear
D.membrane,IgMexpression,E.,lightchainsynthesis
3.humanBlymphocytesurfacedoesnotappear
A.MHCclassImolecules,classB.MHC,classIImolecules,C.C3breceptors
D.EBVreceptor,E.,sheeperythrocytereceptor
4.whichcytokinesarenotproducedbymacrophages?
A.IL-1,B.IL-3,C.,IFN-a,D.,IFN-g,E.,TNF-a
5..ItcanbeactivatedbyPHA.Ithasantigenspecificreceptor,andcanformrosettewithSRBC,andcanproducesecondaryresponse.Accordingtothebiologicalchangesmentionedabove,TandBlymphocytescanbedistinguished
A.++B.++C.,++D.+++E.++
6.whichofthefollowingcellsappearinthethymusmedulla?
A.CD3+,CD8-,CD4-,B.CD3+,CD4+,CD8+,C.CD3+,CD4+,CD8-
D.CD3-,CD4-CD8-,E.CD3-,CD4+,CD8-
7..Lowmolecularweightsecretoryproteinsareexpressedonthesurfaceofthecellmembrane,autocrineandparacrine,andhavebroadbiologicalactivity.Whatarethecharacteristicsofcytokinesintheabovepoints?
A.++B.++C.+++D.+E.++
8.BcellantigenreceptorisIg,theTcellantigenreceptorconsistsoftwopeptides,T,Bcellreceptorsignalingmoleculesareattached,theTcellantigenreceptorbindingsiteissuperantigen.Whichgroupisthecorrectdescriptionoftheantigenreceptordescribedabove?
A.++B.++C.+++D.+E.++
9.CDmoleculesthatbindtoTCRare
A.CD1,B.CD3,C.CD8,D.CD4,E.CD2
10.membranemoleculesthatdonotappearatallstagesofBcelldevelopmentare
A.IgM,B.CD2,C.IgD,D.FcgR,E.C3bR
11.,IL-2,IL-3,IL-4,IL-5.WhatcytokinesareproducedbyTH1?
A.++B.,C.+++D.++E.++
12.cellsthatcanrecognizeantigensspecificallyare
A.MF,T,B.,MF,B,C.T,B,D.,NK,MF,E.T,NK
13.whichofthefollowingcellsexpressMHCclassIImolecules?
A.quiescentBcells,B.quiescentTcells,C.quiescentNKcells
D.stationaryneutrophilE.eosinophils
14.occurredinthethymuscortex,alargenumberofdoublepositivecelldeath,andcompletetheprocessofcloningandelimination,andthedoublepositivecellsdifferentiatedintosinglepositivecells.Whataretheprocessesassociatedwithpositiveselection?
A.++B.++C.+++D.++E.
15..Thymiccortex,thymusmedullaregion,lymphocytesubcortexarea,spleniclymphtissue.
CD4+CD8+cellsmayappearinareasthatare
A.+B.+++C.++D.++E.
16.、thedifferencebetweenBcellandMFisthatthereisFcgRonitssurface,
ThedifferencebetweenBcellsandTcellsisthattherearedifferentantigenreceptors,
ThedifferencebetweenBcellsandNKcellsisthattheycanbeswallowed,
ThedifferencebetweenBcellandMFisthatitscytotoxicityisspecific.
Whichoftheaboveistrue?
A.++B.+C.++D.,E.++
17.TH1differsfromTH2cellsbecause
A.theformerCD4+,andthelatterCD4-
B.theformerproducesIL-4,andthelatterproducesIL-5
C.theformerproducesIFN-a,andthelatterproducesIFN-b
TheformerD.aidstheoccurrenceofdelayedhypersensitivity,andthelattercontributestotheoccurrenceofrapidhypersensitivity
E.theformerreceivesactivationoftheTIantigenandthelatterreceivestheactivationoftheTDantigen
18.signaltransductionmoleculesthatconstitutetheBCRcomplexare
A.IgD,IgM,B.Iga,Igd,C.Igb,Iga,D.Ige.Igd,E.Igb,Igh
19.whichofthefollowingcellsshouldbeexcludedfromfull-timeAPC?
A.
HelperTcellsB.macrophageC.E.dendriticcellsD.BcellsofLangerhanscells
20.,acomplexsignaltransductionmolecule,whichbindsdirectlytofreeantigen,bindsonlytopeptideantigen.Thecodinggeneneedstoberearrangedbygene.WhatarethedifferencesbetweenTCRandBCR?
A.+++B.++C.++D.++E.+II
Whatkindofcellsurfacedoes21.CD40Lmainlyexiston?
A.MFB.Bcell,C.THcell,D.NKcell,E.endothelialcell
22.intheprocessofTHcellactivation,thenonfunctioningsurfacemoleculesofthecellmembraneare
A.CD28,B.CD8,C.CD4,D.CD3,E.TCR
23..Developmenthasnothingtodowithbonemarrow,CD5+,andthecellmembraneexpressesMHCclassIImolecules,andonlyIgMtypeantibodyisproduced.
WhatarethecorrectdescriptionsofB1cells?
A.++B.++C.,+++D.++E.+++
24.、theabilityofantiviralimmunitydecreased,andnograftrejectionoccurred.Still,delayedhypersensitivitycouldbeproduced.PeripheralbloodBlymphocytewasdecreased.Appealtothecaseofcongenitalthymicmice
A.++B.++C.+D.++E.++
25.TCRa/btwomer
A.iscovalentlylinkedtoMHCclassImolecules
InteractionbetweenB.andCD2molecules
C.isnotcovalentlylinkedtotheCD3molecule
D.isthefirstsurfacemarkerinthedifferentiationandmaturationofTcells
ComparedwithSmIg,E.hasmorediversity
26.,therewasaspecificresponsetotheantagonism.Theantigenwasenrichedonthesurfaceofthecell.Itwasfoundinthefolliclesandgerminalcentersofthelymphnodesandexistedinthewhitepulpofthespleen.WhichoftheseareTandBlymphocytesincommon?
A.++B.++C.++D.++E.;
27.whichofthefollowingfitstheclonalselectiontheory?
ReceptorsonthesurfaceofA.lymphocytesproducespecificitybycontactwiththeantigen
ThepreTandpreBcellsintheB.bonemarrowhaveafixedspecificity
C.Bcellsmustundergogeneinducedmutationstocompletegenerearrangement
ThecontactbetweenD.TcellandAPCisthepremiseofclonalselection
E.immatureTandBcellscanberemovedbyexposuretoantigens
28.,PHA,LPS,ConA,PWM.WhichofthesearethemitogensofhumanTcells?
A.++B.,++C.,++D.,++E.+++
29.whichofthefollowingconditionsdoesnotoccurinpatientswithcongenitalcysticorgandefect?
A.lymphnodelacksgerminalcenter
B.circulatinglymphocyteshavenoSmIgmarkers
InC.lymphnodes,thenumberofsecondarycorticalcellsdecreased
D.tonsilatrophy
E.decreasedsplenicplasma
30.whichofthefollowingisnotassociatedwiththeantigenpresentingfunctionofAPC?
A.expressessufficientMHCmolecules
B.antagonism,phagocytosis,treatment
C.formsandproducesantibodies
D.producescertaincytokines
E.expressesaspecificcostimulatoryfactor
31.oftheperipheralblood,Tcellsaccountedforthetotalnumberoflymphocytes
A.10~20%B.20~30%C.40~50%D.60~80%E.<5%
32.oftheperipheralblood,Bcellsaccountedforthetotalnumberoflymphocytes
A.10~15%B.20~25%C.30~40%D.60~80%E.<5%
33.、directbindingoffreeantigen,wemustrecognizetheantigenpeptidebindingwithMHCmolecule,identifythespatialconfigurationdeterminantofepitope,andidentifythelinearpeptidefragmentofantigen.WhatarethecharacteristicsoftheBCRidentificationantigen?
A.++B.++C.++D.+E.
34..Tcellsacquirespecificantigenreceptorsites,Tcellsreacttospecificantigens,TcellsassistBcellstoproduceantibodies,andTcellsdieinlargenumbers.Aboutthethymus,whichoftheabovedescriptioniscorrect?
A.++B.++C.++D.+E.
35.whichofthefollowingisacorrectdescriptionofTCR?
A.canonlyappearonthesurfaceofCD4+cells
B.consistsoffourpeptidechainsa,B,G,andD
C.identifiescomplexesformedbyCD8moleculeswithantigenicpeptides
D.iscomplementarytothedeterminantofcompleteantigenformation
E.isalinkbetweenAPCandTcells
Thirty-six
WhatarethetwopeptidechainsthatmakeupTCR?
AA,II,AB,GG,GD
A.++B.++C.++D.++E.++
Answer:
1.C,2.A,3.E,4.D,6.C,7.E,9.B,10.B,11.A,13.A,14.B,15.E,16.B,17.D,18.C,19.A,20.B,21.C,22.B,23.E,24.A,25.C,26.C,27.E,,28.D,29.C,30.C,,31.D,12.C,32.A,8.E,33.D,5.C,34.E,35.E,36.C
Twofillintheblanks
1,TandBlymphocytesarethetwomostimportantcellsinimmuneresponse.
2,Tcellsaredefinedasdifferentiatedandmaturelymphocytes.
3inthebursaofFabricius(avian)orbonemarrow(mammalian),thelymphocyteasthecentralimmuneorganisthecell.
Theregionof4andTCRisthesiteofantigenspecificbinding.
5.MostTCRconsistofalphaandbetachains,andafewTCRaremadeupofchainsandchains.
6andCD3moleculescombinewithTCRtoformcomplexes,whichhavethefunctionofTCRstructureandsignal.
7,accordingtodifferent,TcellscanbedividedintoCD4+andCD8+twosubpopulations.
8,CD4moleculescombinewithsitesofclassMHCmolecules.
9.CellsurfacemoleculesthatbindtononpolymorphicregionsofclassMHC-Imoleculesare.
10,forTcellactivation,CD28moleculesreceivesignals.
11、theTcellbelongstotheIFN-cellgroupmainlycontainingIL-2,gammaandothercytokines
12、theTcellbelongstotheBcellgroupwhichmainlyproducestheantibody.
13,IL-4andIL-5producingTcellbelongstothecellgroup.
14,doublenegativephaseisinthethymusofTcells,neithertheexpressionofmolecules,butnottoexpressthemolecularstageofdevelopment.
15,theCD4+CD8-cellinthemedullaofthethymusiscalledTcell.
16andBCRarethemolecularstructuresofBcellsurfaceandthesamemembranesurfaceglobulin
Inthe17andBCRcomplexes,CD3likemoleculesarecomposedoftwodistinctdimers.
18.Lymphocyteslackingantigenreceptorsarecells.
19,theantigen
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