1、科技论文邮件英文常有表达1 To further substantiate a role of.2 To gain further insight into the involvement of3 Several lines of evidence suggest a potential role of4 The discrepancies between these studies may be explained in part by the fact that.5 It can also not be excluded that.6 To further elucidate the ro
2、le of.7 There is growing evidence that.8 Several studies indicate that9 It is generally accepted that.10. In vitro studies revealed that.11. This is somewhat surprising since12. Furthermore, available data suggest the potential to.13. development and generation of more specific inhibitors will be re
3、quired to further explore their potential to.14. A better understanding of the regulation of their expression will thus be. instrumental in the development of specific targeting approaches.15. Little is known either on. 16. .remain to be elucidated in more detail17. The aim of this study was to clar
4、ify whether. were therapeutic agents against18. This study may provide a new recognition of natural medicine for the treatment of19. Epidemiological studies have shown the incidence of20. are thought to act through receptor-independent and dependent mechanisms to promote21. .which are derived from.,
5、 have been reported to possess a variety of potent properties, including antioxidant, anti-inflammation, radical-scavenging, and cardiovascular protecting activity, anti-tumor, and so on.22. The purpose of this study was to examine the effects of . and to evaluate the efficacy of cardioprotection by
6、.23. The pathological features of diabetes and/or its complications that were caused by. had been investigated extensively.15. It has been established that TGF-b1 was a major regulator of collagen biosynthesis.16. As discussed above, it was discovered that. showed beneficial influences on.and had ca
7、rdioprotective effects, suggesting that. may ameliorate .17. However, the mechanisms responsible for the effects of.onstill need to be discussed.18. This study elucidated the functional role of . against may provide novel evidence for an antidiabetic property.19. sparked intense debate and research
8、into the cardiovascular security of20. An updated review of21. The significance of this finding rests on the fact that.22. . what is in agreement with literature data23. The value and novelty of this study is to indicate, for the first time in an in vivo model, that the molecular mechanism of athero
9、sclerosis prevention by is consistent with a diminution of the class B scavenger receptor CD36 expression24. The question remains open as to why.25. may lead to a better understanding of the discrepancies among human studies and with the animal ones. 26. .numerous studies suggest that it has a preve
10、ntive role in atherosclerosis, although the mechanism of action still remains unclear.27. The original aim of this study was to establish whether.28. Expression of some of the scavenger receptors is increased at the atherosclerotic lesion,8 but to datethe regulatory mechanisms for most of these gene
11、s are not yet known and could lead to a better understanding of the process, prevention, and therapy of this disease.29. This finding is important in the light of the still unknown mechanism of foam-cell formation from human aortic SMCs.30. The results shown in Figure excluded this hypothesis, 31. T
12、reatment of cells with a-tocopherol (50 mmol/L) resulted in a time-dependent decrease of CD36 protein expression (Figure 2B), as was observed at the mRNA level.32. An understanding of the mechanisms by whichis central to an understanding of 33. remains to be determined.recent data support an importa
13、nt role for.in the pathogenesis of As.34. However, mounting evidence suggests that 35. .although the biological function has not been defined.36. Given the established role of , we explored whether.37. In the following work, we outlined a novel signaling pathway for.these findings suggest an unexpec
14、ted role for .in the pathogenesis of As38. The expression of .in , led us to search for its expression in . To address this issue, we performed IF microscopy using antibodies against.39. To determine whether . was also expressed in., we performed ICH. As shown in figure, the nuclei of .show strong s
15、taining for By contrast, no staining is seen in.40. As anticipated, cells treated withexhibited a reduction in.Unexpectedly,.NO effect was observed with or.this observation suggest that.41. To further characterize the effect of on ., we examined.42. To determine whether.The effect of .were also exam
16、ined in.we also examined the ability of on .This findings indicate that.42. Accordingly, we consider the possibility that.43. Surprisingly, .This results established a link between.and .44. Since Ox-LDL stimulated PPAR expression, we speculated that 45. As demonstrated in., similar results were obta
17、ined when46. We further examined the effect of. the surface expression of CD36 by.47. has been reported previously to be an effective inducer of.induce expression of .in cells.48. induce significant expression of mRNA encoding similar results were obtained whenwas used as.49. to investigate whether.
18、and are linked, we utilized a .that has been demonstrated previously to interfere with.50. while it is possible that .make minor contributions to ,this data indicate that the effect I is mediated primarily by SR CD36.51. The observation that .raised the possibility that.52. To investigate whether.fu
19、nction to regulate transcription of .promoter, 53. to confirm that.collectively , these results suggests that.54. The above findings raised the Intriguing possibility .55. A detailed understanding of the molecular and cellular events that underlie formation of As plaque, is prerequisite to the ratio
20、nal design of the therapeutic of the disease.56. In this work, we have presented evidence implicating.in a novel signaling pathway that regulate differentiation and lipid metabolism in.57. .endows cultured .cells with the ability to bind and internalized OxLDL.58. our observation that.suggest that .
21、may be important for the modulation of gene expression in this context.59. In fact, we have recently demonstrated that .This observation reveals a novel mechanism whereby60. it fits well with the previously defined role of .61. Although prior work has focused primarily on , it is likely that.62. the
22、re is strong evidence that.all of these observations are consistent with our identification .as.63. our findings that , that., and that., collectively suggest that.may play a role in. Clearly, in vivo studies will be required to further address the possibility.64. In the case of , a number of studie
23、s have provided compelling evidence that.65. the work presented herein has in many cases utilized.in an effort/ attempt to.66. It is tempting to speculate that the elucidation of a nuclear receptor signaling pathway involved in.may open the door for therapeutic intervention of this process, 67. sinc
24、e the relationship between . And atherogenesis is complex, the influence ofonmust also be taken into account.68. Clearly, in vivo studies will be required to determine whetherhave potential utility in the treatment or prevention of atherogenesis.69To explore the idea that was used to identify70Furth
25、ermore, these studies demonstrate.to be an important signaling molecule in.and may serve as a therapeutic target in the prevention and treatment of vasculoproliferative disorders72. have been widely used in clinical practise and their efficacy in reducing cardiovascular risk has been well described7
26、3. These results suggest that .has a potent protective effect against. The findings provide a new insight into the mechanism by which74. Despite extensive studies, the fundamental mechanisms responsible for the development and progression of cardiovascular diseases have not yet been fully elucidated
27、. Recent experimental and clinical studies have suggested that reactive oxygen species play a major pathological role75. However, it remains unknown whether.76. .has been shown to possess various pharmacological activities such as anti-oxidative and anti-inflammatory activities.77. recognized as a m
28、olecular target for anti-inflammatory78. Furthermore, we have confirmed an involvement of reactive oxygen species(ROS) in.79. . The present study was attempted to investigate the effect.80. All other reagents were of the best grade commercially available.81. The experiments in this article were cond
29、ucted in accordance with guidelines established by the Animal Care and Use Committee of . University.82. cells were generously provided bymaintained in .83. To elucidate the mechanisms of .action, its effect on .was examined by.84. .may have promising beneficial effects in preventing. and may be of
30、significance from the aspect of.85. In studies of the molecular mechanisms of. A previous report indicated that86. To study the role of. we designed an antisense to deplete the endogenous .protein.87. Consistent with the fact that.dominant-negativedid not rescue the effect of.88. The results present
31、ed above suggest a requirement forin. We further exploredthis possibility using,89. As our results suggested that. we attempted to rescue.90. To further test the relationship of with the91. The activation of . in response to. signalling is required for., and the results presented above suggest that . is a component of this signaling cascade92. To test this hypothesis, we performed. This feature might explain the fact that93. In vivo experiments suggest that .This is supported by the fact
